Đăng xuất
Dosages are expressed throughout in terms of amoxicillin-clavulanate content except when doses are stated in terms of an individual component.
Adults: See Table 2.
Children: Dosage should be expressed in terms of the age of the child and either in mg/kg/day (given in 2 or 3 divided doses). Weighing ≥40 kg: Dose should be according to the adult recommendations.
Children up to 12 years: Recommended Dose: 40 mg/5 mg/kg/day to 80 mg/10 mg/kg/day (not exceeding 3000 mg/375 mg/day) given in 3 divided doses, depending on the severity of infection.
The duration of therapy should be determined by the response of the patient. Some infections (eg, osteomyelitis) require longer periods of treatment.
Premature: No dosage recommendation can be made for this category.
Elderly: No adjustment needed; dose as for adults. If there is evidence of renal impairment, dose should be adjusted as for renally impaired adults.
Renal Impairment: No dose adjustment is required in patients with creatinine clearance (CrCl) >30 mL/min. In patients with CrCl <30 mL/min, the use of Augmentin presentations with an amoxicillin to clavulanic acid ratio of 8:1 is not recommended, as no recommendations for dose adjustments are available.
Haemodialysis: Augmentin 500 mg/62.5 mg powder for oral suspension in sachets should only be used in patients with a creatinine clearance of >30 mL/min.
Hepatic Impairment: Dose with caution; monitor hepatic function at regular intervals. There are insufficient data on which to base a dosage recommendation.
Administration: To minimise potential gastrointestinal intolerance, administer at the start of the meal.
The absorption of Augmentin is optimised when taken at the start of a meal. Treatment should not be extended beyond 14 days without review.
Therapy can be started parenterally and continued with an oral preparation.
